Glucose-6-phosphate dehydrogenase deficiency

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Overview/definition Lancet. 2008 Jan 5;371(9606):64-74. Diseases of erythrocytes can be divided into the affected component of the cell as follows: Hemoglobin (e.g. sickle cell anemia, thalassemia) Membrane-cytoskeleton (e.g. hereditary spherocytosis); and Metabolism (e.g. G6PD deficiency) G6PD deficiency is a common, X-linked reduction in the activity of glucose-6-phosphate dehydrogenase (G6PD), which makes erythrocytes susceptible to oxidative stress… Read more »