Neonatal hyperbilirubinemia

Posted by & filed under Pediatrics.

Definition Am Fam Physician. 2002 Feb 15;65(4):599-606. CMAJ. 2015 Mar 17;187(5):335-43. Pediatr Rev. 2012 Jul;33(7):291-302. More than 80% of newborns will exhibit jaundice, the clinical sign of hyperbilirubinemia, in the first few days of life. Hyperbilirubinemia can be benign at low levels but is harmful to the brain at higher levels.  All newborns will have… Read more »

Rheumatoid arthritis

Posted by & filed under Rheumatology.

Definition N Engl J Med 2011;365:2205-19 Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammatory polyarthritis caused by chronic inflammation of the synovium (the membrane present in synovial joints that lines the joint capsules and produces synovial fluid). Features include synovial inflammation and hyperplasia (which cause joint swelling), autoantibody production, cartilage and bone destruction… Read more »

Juvenile idiopathic arthritis

Posted by & filed under Pediatrics, Rheumatology.

Definition J Rheumatol. 2004 Feb;31(2):390-2. Lancet. 2011 Jun 18;377(9783):2138-49. Juvenile Idiopathic Arthritis (JIA) refers to a heterogeneous group of diseases that share the common feature of arthritis of unknown origin occurring before the age of sixteen. JIA is an inflammatory disorder that primarily affects synovial joints. Each subtype has distinct clinical, immunologic and genetic features. Together, the… Read more »


Posted by & filed under Infectious diseases, Pediatrics, Respirology.

Definition Arch Pediatr Adolesc Med. 2004 Feb;158(2):119-26. Pediatrics. 2006 Oct;118(4):1774-93. Bronchiolitis is the most common lower respiratory illness in children younger than 2. Viral infection, most often with Respiratory Syncytial Virus (RSV) is responsible for inflammation of the respiratory tree, particularly the bronchioles. Both upper and lower respiratory tract symptoms are seen in this illness which, for… Read more »