Sex hormone synthesis, regulation, and function

Posted by & filed under Endocrinology, Obstetrics and gynecology.

Sex hormone synthesis Annu Rev Physiol. 2001;63:193-213. Endocr Rev. 2011 Feb;32(1):81-151. Endocr Rev. 2005 May;26(3):322-30. Fertil Steril. 2002 Apr;77 Suppl 4:S3-5. The hypothalamus-pituitary-gonadal (HPG) axis Sex hormone synthesis is controlled by the pulsatile release of hypothalamic gonadotropin-releasing hormone (GnRH) At the pituitary gland, GnRH stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) into the general circulation… Read more »

Polycystic ovarian syndrome (PCOS)

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Definition J Obstet Gynaecol Can. 2010 May;32(5):423-5, 426-8. Nat Rev Endocrinol. 2011 Apr;7(4):219-31. PCOS is characterized by hyperandrogenism, irregular ovulatory cycles, and a metabolic derangement including glucose intolerance and hyperinsulinemia. Manifestations of PCOS are heterogeneous, and several consensus definitions of the disorder have been produced to describe the disease, with various emphases on clinical or biochemical hyperandrogenism,… Read more »